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KMID : 0438520060130020233
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Journal of the Korean Society of Neonatology
2006 Volume.13 No. 2 p.233 ~ p.243
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Perinatal Outcome in Preterm Infants with Abnormal Umbilical Artery Doppler Results -Emphasizing on Early Onset Thrombocytopenia and its Risk Factors-
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Joung Kyoung-Eun
Kim Jae-Lee
Kim Beyong-Il
Kim Sang-Duk
Kim Ee-Kyung
Choi Jung-Hwan
Kim Do-Hyun
Sim So-Yeon
Kim Eun-Sun
Shin Seung-Han
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Abstract
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Purpose: Umbilical artery Doppler study is a commonly used non-invasive tool in high risk pregnancies because of its good correlation with the degree of placental insufficiency. We analyzed hematologic profiles and perinatal outcome of preterm infants with abnormal umbilical artery Doppler results and the risk factors of early onset thrombocytopenia.
Methods: We retrospectively reviewed the medical records of preterm infants under 35 weeks of gestational age at birth who were admitted to the neonatal intensive care unit of Seoul National University Children’s Hospital from January 1, 2002 through December 31, 2004, and whose mothers had undergone umbilical artery Doppler studies within 5 days before delivery. Sixty two neonates were divided into three groups; the 1st group was defined as the patients with normal umbilical artery (UA) systolic/diastolic (S/D) ratio, the 2nd group, with increased UA S/D ratio above 95 percentile, and the 3rd, with absent or reversed end-diastolic flow (AREDF).
Results: Mean nucleated red blood cell (nRBC) counts per 100 white blood cells (WBCs) were 14.2 (0-150), 91.0 (0-262), 301.4 (6-884) (P<0.001), mean WBC counts were 10.8 (0- 34.1), 9.2(3.4-23.9), 5.9(0.5-15.2) (x1,000/mm(3)) (P=0.007), and mean platelet counts were 215.5+/-69.2, 185.9+/-96.7, 100.2+/-50.3 (x1,000/mL)
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KEYWORD
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Umbilcal artery Doppler, Placental insufficiency, Preterm neonates, Hematolo-gic profile, Nucleated red blood cell, Platelet, Early onset thrombocytopenia
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